Rally 2B

Fetal Growth: One Standard Fits all?

A major focus area of HBGD is preterm birth including prevention and treatment. To intervene, we need to know gestational age. We do not have many good resources for estimating gestational age in many settings. Birth weight often is used as a surrogate, but this measure can vary between populations around the world. Therefore, we need to better understand how growth trajectories differ between populations. The goals for this series of rallies are to evaluate the collection of HBGDki data sets, learn more about how fetal growth trajectories differ between populations, learn how these different trajectories link to gestational age, and learn about the tools that can estimate gestational age more accurately. If there are differences between populations, how much of the differences may be attributed to modifiable or non-modifiable factors?

Focus

Are small for gestational age (SGA) and large for gestational age (LGA) proportions different between countries? What are the results of constructing population fetal growth curves by combining all available data sets and comparing these curves with the INTERGROWTH standard?

Background

Intervention with pre-term birth requires knowing gestational age. There are not many good resources for estimating gestational age in many settings. Birth weight often is used as a surrogate, but this measure can vary between populations.

value

This rally showed marked variation in fetal growth parameters and birth outcomes between different countries. Longitudinal plots of fetal growth parameters varied from the INTERGROWTH fetal growth standard. Subsequent sprints are necessary to confirm this result and better understand the basis for the observed variation.