Rally 5A

Gestational Age Shift Analysis

The overall purpose of this project is to quantify the effects that extending gestational age at birth could have on reducing overall mortality and morbidity of preterm infants across the gestational age. This will help in quantifying the benefits of a potential intervention (i.e., "lives saved or improved") as well as compare the utility of different interventions.


The focus of this first two-week rally sprint: using US data, if we could shift the gestational age of 26-29 week-olds by 1, 2, 3, 4 weeks, what would be the impact on mortality?


At each point along the gestational age range (generally measured in whole weeks) there are related outcome data, including frequency of 'attempted' live births, as well as relative risks which include mortality, hospitalization rates (NICU days), birth weight, and neurocognitive development. Most studies to date have only focused on one of these concepts. Also, most granular data is from high income settings. We will be using whatever data that exist today to derive the model and will make assumptions on what would happen if this were to be replicated in low income settings where the data is sparse.


Not specified.